Two days ago, a Michigan doctor wrote a compelling opinion piece in the Detroit News about how COVID-19 is “its own animal,” and how much of what he’s learned to treat over the years doesn’t apply to this disease.

Beaumont doctor Christopher R. DeAngelis wrote:

I completed four days as the attending physician on a COVID-19 floor at my local hospital, and here is some of what I learned:

First, this is like nothing we have seen before. This virus is its own animal — it’s totally different in so many ways. As a physician, so much of what I’ve learned to treat over the years does not apply. Throw conventional wisdom out the window.

Thought we treated sepsis with fluids? Think again.

Thought we treated chronic obstructive pulmonary disease exacerbations with steroids? Think again.

Thought we ventilated people with pneumonia on their backs? Think again.

Think we knew much about anything?

He added:
I have some guarded hope for treatment. This virus is nasty. I’m the first to admit that I did not “get it.” Now I do. All of the practitioners on the front lines see how bad it can be. I won’t quote outcomes, but we’re gathering data as we go. There will be more studies published over the next few months than can be digested in a lifetime. I don’t claim to be any authority. Most of us only have observational, nonscientific analysis, but I had some positive results. Yes, I think I did.
I ran a floor of COVID-19 positive patients with severe symptoms. Our team used the combo of hydroxychloroquine with azithromycin and it seemed to help! Of the patients that I treated for these four days who where acutely ill — all ages and health conditions — most (loosely defined and footnoted) seemed to improve and were able to be discharged home. I can say that I transferred no one to the ICU but I sent many people home.
Another doctor, New York City ER and Critical Care Physician Cameron Kyle-Sidell appears to support Doctor DeAngelis’ claims about throwing out conventional wisdom, in two videos he posted to YouTube that warn doctors are not properly using ventilators to treat patients with COVID-19.

The NYC ER physician starts his video by saying, “things are not good” in New York, adding, “our therapies are not working,” and “people are dying of a disease that we do not understand.” Dr. Kyle-Sidell insists that doctors need to start treating this like a “new disease, requiring new treatment” if they’re going to defeat it.

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In his next video, Dr. Kyle-Sidwell begins “I believe we are treating the wrong disease.”

“In short, I believe we are treating the wrong disease, and I fear that this misguided treatment will lead to a tremendous amount of harm to a great number of people in a very short time. I feel compelled to give this information out.

COVID-19 lung disease, as far as I can see— is not a pneumonia and should not be treated as one. Rather, it appears as if some kind of viral-induced disease most resembling high altitude sickness. Is it as if tens of thousands of my fellow New Yorkers are on a plane at 30,000 feet at the cabin pressure is slowly being let out. These patients are slowly being starved of oxygen.

I’ve seen patients depending on oxygen take off their oxygen and quickly progress through a state of anxiety and emotional distress, and eventually blue in the face in the face. And while patients absolutely look like patients on the brink of death, they do not look like patients dying from pneumonia. I suspect that the patients I’m seeing in front of me, look as if a person was dropped off on the top of Mt. Everest without time to acclimate.

I don’t know the final anwer of this disease, but I’m quite sure that a ventilator is not it. That’s not to say that we don’t need ventilators, we absolutley need them. They  are the only way that we are able to give a little more oxygen to people who need it. But when we treat people with ARDS, we typically use ventilators to treat what’s called a respiratory failure. That is, we use the ventilator to do the work the patient’s muscles can no longer do, because they’re too tired to do it. But these patients’ muscles work fine.

I fear that if we are using a false paradigm to treat a new disease, then the method that we program into the ventilator, one based on respiratory failure as opposed to oxygen failure, that this method being widely adopted, aims to increase pressure on the lungs in order to open them up, is actually doing more harm than good, and that the pressure we are providing to lungs, we may be providing to lungs that cannot take it. And that the ARDS that we are seeing, may be nothing more than lung injury caused by the ventilator.”

Finally, he warns, that he believes we can use the ventitlators in a much safer way, saying: “There are hundreds of thousands of lungs in this country at risk.”

Watch:

Mike Coudrey posted a very interesting series of tweets yesterday, explaining how new research shows that COVID-19 is being actually starving the body of oxygen.

Here is the string of Coudrey’s tweets in a condensed version:

NEW RESEARCH: COVID-19 is causing prolonged & progressive hypoxia (starving your body of oxygen) by binding to the heme groups in hemoglobin in your red blood cells.

Patients are progressively desaturating (losing o2 in their blood), & as a result, it’s leading to organ failures

COVID-19 glycoproteins bond to the heme groups, and in doing so the oxidative iron ion is “disassociated” (released) from red blood cells.

Without the iron ion, hemoglobin can no longer bind to oxygen, rendering the red blood cells useless.

It is very likely that this is more the case, rather than developing a form of ARDS or pneumonia.

Many doctors are starting to believe that they are operating under a false notion of pneumonia, & possibly treating the wrong symptoms on a systematic basis throughout the country.

Ventilators may not be treating the root cause, as many of the patient’s lungs aren’t ‘tiring out’, they’re pumping just fine.

It is instead that the affected hemoglobin have been stripped of their ability to carry oxygen, resulting in hypoxia.

Courdrey’s tweets continue:

The body compensates for this lack of o2 carrying capacity by having your kidneys release hormones like erythropoietin, which tell your bone marrow factories to ramp up production on new red blood cells with freshly made and fully functioning hemoglobin.

This is the reason you find elevated hemoglobin and decreased blood oxygen saturation as one of the 3 primary indicators of poor prognosis for a particular patient.

If the patient’s immune system doesn’t fight off the virus in time before their blood oxygen saturation drops too low, ventilator or no ventilator, organs start shutting down.

The only way to try to keep them going is by delivering oxygen or a transfusion of red blood cells.

This is why it is absolutely crucial to treat patients in an outpatient setting with hydroxychloroquine and azithromycin, before they deteriorate and have to go to the ICU.

Hydroxychloroquine is also used for malaria, a pathogen that also interferes with the red blood cells. Malaria uses host hemoglobin as its food source.

HCQ interferes with COVID-19 surface spike proteins and prevents them from dislodging the hemoglobin in the red blood cells.

HCQ also effects some aspects of cellular PH, preventing viral replication and entry.

In conclusion, Physicians may need to re-evaluate treatment options and their basis-of-understanding for COVID-19, in light of its newly realized ability to induce hypoxemia in the patient.

Coudrey explains why it’s “crucial” to treat patients in an “outpatient” setting with hydroxychloroquine and azithromycin before they deteriorate and end up in ICU.

 

Adding:

Reactive oxygen species in erythrocytes are generated through heme degradation.

Displaced Fe, released after viral attack on hemoglobin, is thought to be responsible for extensive free radical damage to the lungs.

Coudrey asks everyone to please watch this video from Dr. Cameron Kyle-Sidell, who works in an intensive care unit in New York. He also provides research by Sichuan University of Science & Engineering

The novel coronavirus pneumonia (COVID-19) is an infectious acute respiratory infection caused by the novel coronavirus. The virus is a positive-strand RNA virus with high homology to bat coronavirus. In this study, conserved domain analysis, homology modeling, and molecular docking were used to compare the biological roles of certain proteins of the novel coronavirus. The results showed the ORF8 and surface glycoprotein could bind to the porphyrin, respectively. At the same time, orf1ab, ORF10, and ORF3a proteins could coordinate attack the heme on the 1-beta chain of hemoglobin to dissociate the iron to form the porphyrin. The attack will cause less and less hemoglobin that can carry oxygen and carbon dioxide. The lung cells have extremely intense poisoning and inflammatory due to the inability to exchange carbon dioxide and oxygen frequently, which eventually results in ground-glass-like lung images. The mechanism also interfered with the normal heme anabolic pathway of the human body, is expected to result in human disease. According to the validation analysis of these finds, chloroquine could prevent orf1ab, ORF3a, and ORF10 to attack the heme to form the porphyrin, and inhibit the binding of ORF8 and surface glycoproteins to porphyrins to a certain extent, effectively relieve the symptoms of respiratory distress. Favipiravir could inhibit the envelope protein and ORF7a protein bind to porphyrin, prevent the virus from entering host cells, and catching free porphyrins. Because the novel coronavirus is dependent on porphyrins, it may originate from an ancient virus. Therefore, this research is of high value to contemporary biological experiments, disease prevention, and clinical treatment.

If this new research about how COVID-19 attacks our bodies is accurate, why are Democrat lawmakers, pundits and their allies in the media fighting so hard to keep the narrative alive that hydroxychloroquine is a dangerous solution to treat COVID-19, and the only cure lies in the acquisition of more ventilators?

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