In a preprint paper, researchers wrote the risk of febrile seizure following monovalent COVID-19 mRNA inoculation among children aged 2-5 years was “significantly elevated” shortly after the injection.

” In this self-controlled case series that included participants aged 2-5 years from three commercial insurance databases, the incidence rate ratio of febrile seizures was significantly elevated in the 0-1 days following mRNA-1273 administration,” the researchers wrote.

“The incidence of febrile seizures was elevated immediately following vaccination with the monovalent mRNA-1273 COVID-19 vaccine in children aged 2-5 years,” they continued.

Despite these findings, the researchers still said “the safety profile of monovalent mRNA vaccines remains favorable for use in young children.”

Unsurprisingly, U.S. Food and Drug Administration (FDA) researchers conducted the study.

“The incidence of febrile seizures was 2.5 times higher among children zero to one day after a Moderna shot, compared to the same children eight to 63 days after vaccination, the researchers said,” Chief Nerd noted.

“There was also a higher risk for febrile seizures zero to one day after receipt of a Pfizer-BioNTech dose, compared to the same 8–63 day window following vaccination, but that elevated risk was not statistically significant. The study was carried out after the researchers identified seizures/convulsions as a safety signal among children aged 2 to 4 following receipt of Pfizer’s shot and among children aged 2 to 5 after a Moderna jab,” Chief Nerd added.

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Further research was needed because the method of identification, near real-time surveillance, “was designed to be sensitive but not specific for screening and detection purposes,” the researchers said. Febrile seizures became the focus because most of the cases identified in the prior study were seizures of that type.

The two-day window utilized in the new study ensures the seizure cases “are more likely to be associated with vaccination rather than other causes,” the researchers said.

There were 88 febrile seizures after the Pfizer vaccination among the study population. Seven of those cases happened the day of, or the day after, vaccination.

There were 67 cases after the Moderna vaccination. Ten happened in the two-day window.

Seizures that happened two to seven days after vaccination were excluded from the primary analysis.

In a secondary analysis, using a longer risk interval within seven days of vaccination, researchers identified 103 febrile seizures and 135 seizures/convulsions after Pfizer vaccination, including 22 febrile seizures and 32 seizures/convulsions within seven days of a shot. The secondary analysis showed 78 febrile seizures and 106 seizures/convulsions after Moderna vaccination, including 21 febrile seizures and 28 seizures/convulsions in the longer risk interval.

Read the full preprint paper HERE.

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