Scientists with Moderna, a manufacturer of experimental mRNA COVID-19 shots, released a paper saying the technology used in the gene therapy carries toxicity risks.

The paper, titled ‘Strategies to reduce the risks of mRNA drug and vaccine toxicity’, was published by Nature Reviews Drug Discovery on January 23rd.

“mRNA formulated with lipid nanoparticles is a transformative technology that has enabled the rapid development and administration of billions of coronavirus disease 2019 (COVID-19) vaccine doses worldwide. However, avoiding unacceptable toxicity with mRNA drugs and vaccines presents challenges,” the paper read.

“Lipid nanoparticle structural components, production methods, route of administration and proteins produced from complexed mRNAs all present toxicity concerns. Here, we discuss these concerns, specifically how cell tropism and tissue distribution of mRNA and lipid nanoparticles can lead to toxicity, and their possible reactogenicity,” it continued.

“We focus on adverse events from mRNA applications for protein replacement and gene editing therapies as well as vaccines, tracing common biochemical and cellular pathways,” the scientists added.

The Epoch Times reports:

Authors of the paper include Moderna employees Eric Jacquinet and Dimitrios Bitounis and Maximillian Rogers, who was working at Moderna when the paper was being done.

Moderna didn’t respond to a request for comment.

The mRNA vaccines have multiple known side effects, including heart inflammation and severe allergic shock. Those may stem from hypersensitivity reactions, which can be elicited by “any LNP-mRNA component” but are most likely triggered by PEGlyated lipid nanoparticles, which is “the most potentially reactogenic component,” according to the scientists.

Polyethylene glycol, or PEG, an ingredient in the Pfizer and Moderna COVID-19 vaccines, is known to cause allergic reactions. Outside scientists are divided over the mechanism behind the heart inflammation, while Pfizer has posited that the LNPs are behind the issue.
The new paper drew from prior publications and other data. The authors didn’t carry out any new experiments.

Some of the papers cited included those that have found mRNA and the spike protein delivered by Moderna’s vaccine in various parts of human beings weeks or months after vaccination, despite health officials claiming when the vaccines were rolled out that such materials would exit the body within days.

Despite the toxicity risks and known side effects of mRNA technology, Moderna has dozens of mRNA products in its pipeline.

The biotechnology company recently began conducting trials for an mRNA cancer vaccine in the United Kingdom.

Moderna Begins Trial For New mRNA ‘Vaccine’

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